Methamphetamine is commonly known as Crystal Meth, Meth, and Speed. It is a neurotoxin and potent psychostimulant that is used to treat attention deficit hyperactivity disorder (ADHD) and obesity. It exists as both dextromethamphetamine and levomethamphetamine. Dextromethamphetamine is a stronger central nervous stimulant than levomethamphetamine; however, both are highly addictive and produce the same toxicity symptoms at high doses. Although rarely prescribed due to the risks, methamphetamine hydrochloride is approved by the United States Food and Drug Administration, under the trade name Desoxyn.
The picture below represents the mathamphetamine molecule.
external image Methamphetamine3Dan.gif

Recreationally, meth is used to:
  • Increase sexual desire
  • Lift the mood
  • Increase energy

Which allow users to engage in sexual activity continuously for several days straight.

In low doses, methamphetamine can cause:
  • Elevated mood
  • Increased alertness
  • Concentration
  • Energy in fatigued individuals

In higher doses it can induce:
  • Psychosis
  • Rhabdomyolysis
  • Cerebral hemorrhage

Methamphetamine is known for its high potential for addiction and abuse. It is also more likely to take user who quit for a ride with its often occurring post-withdrawal
syndrome.

Post-withdrawal Syndrome is a syndrome that can persist for months beyond the typical withdrawal period. Unlike cocaine, methamphetamine is neurotoxic to humans, which roughly translates to chemically induced permanent brain alterations, as well as damages to your central nervous system by inducing damage to both dopamine and serotonin neurons.

Get comfy because the list of side effects will take at least 3 minutes to read fully:


Physical

The physical side effects of methamphetamine can include:
  • Anorexia
  • Hyperactivity
  • Dilated pupils
  • Flushed skin
  • Excessive sweating
  • Increased movement
  • Dry mouth and bruxism (leading to meth mouth)
  • Headache
  • Irregular heartbeat
  • Rapid breathing
  • High or low blood pressure
  • High body temperature
  • Diarrhea
  • Constipation
  • Blurred vision
  • Dizziness
  • Twitching
  • Numbness
  • Tremors
  • Dry skin
  • Acne
  • Pallor


Meth Mouth

Methamphetamine users and addicts may lose their teeth abnormally quickly, regardless of the route of administration, from a condition known as meth mouth. The condition is generally more severe in users who inject the drug, rather than those who smoke, ingest or inhale it.


Psychological

The psychological effects of methamphetamine can induce:
  • Euphoria
  • Dysphoria
  • Changes in libido
  • Alertness
  • Apprehension
  • Concentration
  • Decreased sense of fatigue
  • Insomnia
  • Self-confidence
  • Sociability
  • Irritability
  • Restlessness
  • Grandiosity
  • Repetitive and obsessive behaviors
  • Anxiety
  • Depression
  • Psychosis
  • Suicide
  • Violent behaviors
  • High rate of addiction


Neurotoxicity

Methamphetamine is directly neurotoxic to dopamine neurons. Moreover, methamphetamine abuse is associated with an increased risk of Parkinson's disease. Similar to the neurotoxic effect on the dopamine system, methamphetamine can also result in neurotoxicity to serotonin neurons. It has been demonstrated that a high core temperature is correlated with an increase in the neurotoxic effects of methamphetamine. As a result of the effect to dopamine neurons, chronic use may lead to post acute withdrawal which persist beyond the withdrawal period for months, even up to a year.


Dependence, Addiction and Withdrawal

Tolerance is expected to develop with regular methamphetamine use, and when abused, this tolerance develops rapidly.
In highly dependant amphetamine and methamphetamine abusers, "when chronic heavy users abruptly discontinue [methamphetamine] use, many report a time-limited withdrawal syndrome that occurs within 24 hours of their last dose."

There is an 87.6% rate of users who suffer from withdrawal. Withdrawal persists for three to four weeks with a marked "crash" phase during the first week.

Withdrawal symptoms can include:
  • Anxiety
  • Drug craving
  • Dysphoric mood
  • Fatigue
  • Increased appetite
  • Increased movement
  • Decreased movement
  • Lack of motivation
  • Sleeplessness
  • Sleepiness
  • Vivid dreams
  • Lucid dreams

The severity of the withdrawal symptoms are correlated to the tolerance and dependence of the user.


Overdose

An overdose on methamphetamine intoxication may result in many symptoms. A moderate overdose of methamphetamine may induce symptoms such as:
  • Abnormal heart rhythm
  • Confusion
  • Dysuria
  • High or low blood pressure
  • Hyperthermia
  • Hyperreflexia
  • Myalgia
  • Severe agitation
  • Tremor
  • Urinary hesitancy
  • Urinary retention

A methamphetamine overdose will likely also result in mild brain damage, due to the dopaminergic and serotonergic neurotoxicity

Death from fatal methamphetamine poisoning is typically preceded by convulsions and coma.


References

http://upload.wikimedia.org/wikipedia/en/4/49/Methamphetamine3Dan.gif
http://en.wikipedia.org/wiki/Methamphetamine
http://www.jcsd.org/Meth%20Symptoms.htm

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